Catalog
2014-15

Biochemistry & Chemistry

Dr. John Regan
Chair of the Department

The goals of the chemistry and biochemistry department are to provide a program which emphasizes the basic understanding of the constituents of matter, its transformations and the chemical principles involved therein. The department also promotes the study of the chemical and biochemical systems and the manner and methods by which they are investigated. To accomplish this goal, students are provided with a basic framework of knowledge by which they can carry out further study, research and understand the implication of scientific discoveries, inventions and their impact upon human welfare. They learn to think analytically and independently and are encouraged to apply this knowledge ethically throughout their lifetimes to civic, personal and professional problems. As a result, students are prepared for careers in the various disciplines and sub-disciplines of chemistry and biochemistry, in the teaching of these disciplines and for pursuing higher studies in basic and applied sciences or to follow professional careers in medicine, dentistry, law and other areas.

B.S. Major in Chemistry

Students in this program must maintain a 2.8 GPA in the major by the end of the fourth semester. Students who do not maintain this GPA are advised not to continue in the chemistry major. The following chemistry courses are required:

CHEM 101General Chemistry I4
CHEM 102General Chemistry II4
CHEM 302Analytical Chemistry5
CHEM 309Physical Chemistry I3
CHEM 310Physical Chemistry II3
CHEM 311Physical Chemistry Laboratory I2
CHEM 319Organic Chemistry I3
CHEM 320Organic Chemistry II3
CHEM 323Organic Chemistry Laboratory I2
CHEM 324Organic Chemistry Laboratory II2
CHEM 335Inorganic Chemistry3
CHEM 336Inorganic Chemistry Laboratory2
CHEM 410Physical Chemistry Laboratory II2
CHEM 437Computers, Structures and Bonding3
CHEM 452Advanced Spectroscopy5

A minimum grade of C in any chemistry course is necessary for credit toward the major. Majors may not elect CHEM 100 Foundations of Chemistry, CHEM 105 General Chemistry I, or CHEM 106 General Chemistry II. The chemistry department is approved by the American Chemical Society and will certify students as having complied with the Society requirements provided they have completed the minimum requirements for the B.S. plus CHEM 433 Biochemistry I and one additional 400 level course.

B.S. Major in Biochemistry

Students in this program must maintain a 2.8 GPA in the major by the end of the fourth semester. Students who do not maintain this GPA are advised not to continue in the biochemistry major. The following chemistry courses are required:

CHEM 101General Chemistry I4
CHEM 102General Chemistry II4
CHEM 302Analytical Chemistry5
CHEM 309Physical Chemistry I3
CHEM 310Physical Chemistry II3
CHEM 311Physical Chemistry Laboratory I2
CHEM 319Organic Chemistry I3
CHEM 320Organic Chemistry II3
CHEM 323Organic Chemistry Laboratory I2
CHEM 324Organic Chemistry Laboratory II2
CHEM 335Inorganic Chemistry3
CHEM 410Physical Chemistry Laboratory II2
CHEM 433Biochemistry I3
CHEM 434Biochemistry II3
CHEM 436Biochemistry Laboratory2
CHEM 437Computers, Structures and Bonding3
CHEM 457Biochemistry III3
CHEM 459Biochemistry III Laboratory2
BIOL 111
  & BIOL 112
General Biology I
   and General Biology II
4
BIOL 113
  & BIOL 114
General Biology Laboratory I
   and General Biology Laboratory II
4
Advanced Biology Elective3

A minimum grade of C in any chemistry or biology course is necessary for credit toward the major. Majors may not elect CHEM 100 Foundations of Chemistry, CHEM 105 General Chemistry I, or CHEM 106 General Chemistry II. Students planning to enter either medical or dental school should consult with the Premedical Advisory Committee and should acquaint themselves with the entrance requirements of medical or dental schools. Students pursuing the B.S. degree in biochemistry may, through the judicious choice of electives comply with the American Chemical Society requirements for certification.

B.A. Major in Chemistry

Students in this program must successfully complete the following courses with a minimum grade of C:

CHEM 101
  & CHEM 102
General Chemistry I
   and General Chemistry II
8
CHEM 319
  & CHEM 320
Organic Chemistry I
   and Organic Chemistry II
6
CHEM 323
  & CHEM 324
Organic Chemistry Laboratory I
   and Organic Chemistry Laboratory II
4
After completion of the preceeding courses, students must take the following:16
Analytical Chemistry
Physical Chemistry I
Physical Chemistry II
Physical Chemistry Laboratory I
Chemistry Elective3-5

B.A. Major in Biochemistry

Students in this program must successfully complete the following courses with a minimum grade of C:

CHEM 101
  & CHEM 102
General Chemistry I
   and General Chemistry II
8
CHEM 319
  & CHEM 320
Organic Chemistry I
   and Organic Chemistry II
6
CHEM 323
  & CHEM 324
Organic Chemistry Laboratory I
   and Organic Chemistry Laboratory II
4
BIOL 111
  & BIOL 112
General Biology I
   and General Biology II
4
BIOL 113
  & BIOL 114
General Biology Laboratory I
   and General Biology Laboratory II
4
After completion of the preceeding courses, students must take the following:21
Analytical Chemistry
Physical Chemistry I
Biochemistry I
Biochemistry II
Biochemistry Laboratory
Biochemistry III
Biochemistry III Laboratory

Undergraduate research is encouraged and the department is equipped with state-of-the-art instrumentation that is available for student use. Included are a Fourier-transform infrared spectrophotometer, an X-ray crystallography apparatus, a diode-array UV/visible spectrophotometer, a Fourier-transform nuclear magnetic resonance spectrophotometer, an atomic absorption unit, several high performance liquid chromatographs, gas chromatographs, and a molecular modeling laboratory.

Students who transfer into the chemistry and biochemistry programs are required to take at least half of their required chemistry credits at Manhattan College.

Minor in Chemistry

Students should complete the following courses (or their corresponding Honors Course) in the Department of Chemistry and Biochemistry for the minor. A minimum grade of C is required for all courses.

CHEM 101
  & CHEM 102
General Chemistry I
   and General Chemistry II
8
CHEM 319
  & CHEM 320
Organic Chemistry I
   and Organic Chemistry II
6
One additional course selected from CHEM 302, CHEM 309, CHEM 310, CHEM 335 or CHEM 421.3

 Minor in Biochemistry

Students should complete 15 credits or five course in the Department of Chemistry and Biochemistry for the minor. These credits must include at least 8 credits from the following courses. A minimum grade of C is required for all courses. A student may not count the same credits towards minors in both chemistry and biochemistry

CHEM 433Biochemistry I3
CHEM 434Biochemistry II3
CHEM 436Biochemistry Laboratory2
CHEM 457Biochemistry III3
CHEM 459Biochemistry III Laboratory2

Bachelor of Science in Chemistry

First Year
FallCreditsSpringCredits
CHEM 1014CHEM 1024
MATH 1853MATH 1863
ENGL 1103RELS 1103
SCI 1001LLRN 102 or PHIL 2133
Social Sciences3MLL3
MLL3 
 17 16
Second Year
FallCreditsSpringCredits
CHEM 3193CHEM 3203
CHEM 3232CHEM 3242
MATH 2853CHEM 3353
HIST 1503CHEM 3362
ENGL 1503MATH 2863
MUSC 150 or ART 1503PHIL 1503
 17 16
Third Year
FallCreditsSpringCredits
CHEM 3025CHEM 3103
CHEM 3093CHEM 3112
PHYS 1014PHYS 1024
RELS Catholic Studies3CHEM 4373
 RELS Global/Contemporary3
 15 15
Fourth Year
FallCreditsSpringCredits
CHEM 4102CHEM 4525
Social Sciences3Electives111
Humanities Elective3 
Electives19 
 17 16
Total Credits: 129
1

For American Chemical Society Certification, 6 credits of electives must include CHEM 433 Biochemistry I.

Bachelor of Arts in Chemistry

First Year
FallCreditsSpringCredits
CHEM 1014CHEM 1024
ENGL 1103Social Sciences3
LLRN 102 or PHIL 2133MATH 1863
MATH 1853RELS 1103
SCI 1001MLL3
MLL3 
 17 16
Second Year
FallCreditsSpringCredits
CHEM 3193CHEM 3203
Computer Science23CHEM 3242
CHEM 3232Electives13
MATH 2853ENGL 1503
Electives13PHIL 1503
HIST 1503HSS3
 17 17
Third Year
FallCreditsSpringCredits
PHYS 101 or 1074PHYS 102 or 1084
CHEM 3025Social Sciences3
RELS Catholic Studies3MUSC 150 or ART 1503
Electives13Electives16
 15 16
Fourth Year
FallCreditsSpringCredits
CHEM 3093CHEM 3103
CHEM Elective3CHEM 3112
RELS Global/Contemporary3HSS Elective3
HSS Elective3Electives16
Electives13 
 15 14
Total Credits: 127
1Of the 24 free electives allowed in the BA Chemistry program, at least six must be earned in the humanities or social sciences and six in the natural sciences or mathematics.
2Can be CHEM 437 Computers, Structures and Bonding or other computer course to be determined in consultation with advisor.

Bachelor of Science in Biochemistry

First Year
FallCreditsSpringCredits
CHEM 1014CHEM 1024
BIOL 1112BIOL 1122
BIOL 1132BIOL 1142
MATH 1853MATH 1863
ENGL 1103RELS 1103
LLRN 102 or PHIL 2133Social Sciences3
SCI 1001 
 18 17
Second Year
FallCreditsSpringCredits
CHEM 3193CHEM 3203
CHEM 3232CHEM 3242
MATH 2853CHEM 3353
PHYS 101 or 1074PHYS 102 or 1084
MLL3MLL3
 15 15
Third Year
FallCreditsSpringCredits
CHEM 3025CHEM 3103
CHEM 3093CHEM 3112
CHEM 4333CHEM 4343
HIST 1503CHEM 4362
 CHEM 4373
 ENGL 1503
 14 16
Fourth Year
FallCreditsSpringCredits
CHEM 4102CHEM 4592
CHEM 4573MUSC 150 or ART 1503
Adv. BIOL Elective3PHIL 1503
Electives6Social Sciences3
RELS Catholic Studies3RELS Global/Contemporary3
 Electives3
 17 17
Total Credits: 129
1The advanced biology elective to be chosen from the following courses: BIOL 217 Genetics (Co-requisite BIOL 218 Lab), BIOL 225 Microbiology (Co-requisite: BIOL 226 Lab), BIOL 319 Cellular Biochemistry/Physiology (Co-requisite: BIOL 323 Lab), BIOL 320 Animal Physiology (Co-requisite: BIOL 324 Lab), BIOL 321 Molecular Cell Biology (Co-requisite: BIOL 322 Lab) or BIOL 405 Neurobiology after individual consultation with and approval by the Chemistry Department Chair.

Bachelor of Arts in Biochemistry

First Year
FallCreditsSpringCredits
BIOL 1112BIOL 1122
BIOL 1132BIOL 1142
CHEM 1014CHEM 1024
ENGL 1103Social Sciences3
LLRN 102 or PHIL 2133RELS 1103
SCI 1001MLL3
MLL3 
 18 17
Second Year
FallCreditsSpringCredits
CMPT Elective23Advanced BIOL33
CHEM 3193CHEM 3203
CHEM 3232CHEM 3242
MATH 1853MATH 1863
HIST 1503PHIL 1503
ENGL 1503 
 17 14
Third Year
FallCreditsSpringCredits
CHEM 4333CHEM 4343
PHYS 101 or 1074CHEM 4362
Electives19PHYS 102 or 1084
 Electives16
 16 15
Fourth Year
FallCreditsSpringCredits
CHEM 3025CHEM 4592
CHEM 3093Social Sciences3
CHEM 4573RELS Global/Contemporary3
MUSC 150 or ART 1503Electives16
RELS Catholic Studies3 
 17 14
Total Credits: 128
1Of the 21 free electives allowed in the BA Chemistry program, at least six must be earned in the humanities or social sciences and six in the natural sciences or mathematics.
2Can be CHEM 437 Computers, Structures and Bonding or other computer course to be determined in consultation with advisor.
3

The advanced biology elective to be chosen from the following courses: BIOL 217 Genetics (Co-requisite BIOL 218 Lab), BIOL 225 Microbiology (Co-requisite: BIOL 226 Lab), BIOL 319 Cellular Biochemistry/Physiology (Co-requisite: BIOL 323 Lab), BIOL 320 Animal Physiology (Co-requisite: BIOL 324 Lab), BIOL 321 Molecular Cell Biology (Co-requisite: BIOL 322 Lab) or BIOL 405 Neurobiology after individual consultation with and approval by the Chemistry Department Chair.

For American Chemical Society Certification, 6 credits of electives must include CHEM 433 Biochemistry I.

Courses

CHEM 100. Foundations of Chemistry. 3 Credits.

A course in fundamental principles and applications of chemistry to the living world. Two lectures and one two-hour laboratory period. This course is designed for students majoring in the Arts, in Physical Education, or in Radiological Sciences and cannot be used as a substitute for any other course in chemistry.

CHEM 101. General Chemistry I. 4 Credits.

The fundamental laws and principles of chemistry; appropriate laboratory exercises to illustrate these principles and to develop proper techniques; introduction to quantitative analytical methodology. Three lectures and one three-hour laboratory period per week. Prerequisite for CHEM 101: a high school chemistry course or CHEM 100. It is recommended that a student achieve a grade of C or higher in CHEM 101 before taking CHEM 102.

CHEM 102. General Chemistry II. 4 Credits.

The fundamental laws and principles of chemistry; appropriate laboratory exercises to illustrate these principles and to develop proper techniques; introduction to quantitative analytical methodology. The laboratory includes an introduction to systematic inorganic qualitative analysis. Three lectures and one three-hour laboratory period per week. Prerequisite: CHEM 101. It is required that a student achieve a grade of C or higher in CHEM 101 before taking CHEM 102.

CHEM 103. General Chemistry Laboratory I. 0 Credits.

CHEM 104. General Chemistry Laboratory II. 0 Credits.

CHEM 105. General Chemistry I. 4 Credits.

An introductory course in the principles of chemistry, with application to the health sciences. Fundamentals of general chemistry, organic chemistry and biochemistry. Appropriate laboratory exercises illustrate these principles and develop techniques. This course cannot be taken as a prerequisite for Organic Chemistry. Three lectures and one three-hour laboratory period per week.

CHEM 106. General Chemistry II. 4 Credits.

An introductory course in the principles of chemistry, with application to the health sciences. Fundamentals of general chemistry, organic chemistry and biochemistry. Appropriate laboratory exercises illustrate these principles and develop techniques. This course cannot be taken as a prerequisite for Organic Chemistry. Three lectures and one three-hour laboratory period per week.

CHEM 197. General Chemistry: Honors. 4 Credits.

An intensive introductory course in all the major branches of chemistry, including biochemistry. The level at which material is introduced will vary so as to adjust to the backgrounds of the students. The laboratory will include some open ended experiments designed to develop an appreciation for creative research. Admission to the course is by invitation of the professor in charge of the course and is not restricted to chemistry majors. Three lectures and one three-hour laboratory period per week. Registration only with permission of instructor.

CHEM 198. General Chemistry: Honors. 4 Credits.

An intensive introductory course in all the major branches of chemistry, including biochemistry. The level at which material is introduced will vary so as to adjust to the backgrounds of the students. The laboratory will include some open ended experiments designed to develop an appreciation for creative research. Admission to the course is by invitation of the professor in charge of the course and is not restricted to chemistry majors. Three lectures and one three-hour laboratory period per week. Registration only with permission of instructor.

CHEM 302. Analytical Chemistry. 5 Credits.

Principles and applications of classical wet analytical techniques such as gravimetric and volumetric methods, as well as modern analytical techniques, such as electrochemistry, spectroscopy and chromatography. Statistical evaluation of analytical data. Three lectures and a four hour laboratory. Prerequisite: A grade of C or better in CHEM 102.

CHEM 309. Physical Chemistry I. 3 Credits.

The application of thermodynamics to the study of the states of matter, phase equilibria, chemical equilibria, thermal chemistry, and electrochemistry. Chemical kinetics, diffusion and the migration of ions. Elucidation of the molecular structure of matter by classical physical and quantum mechancial considerations. Prerequisite: A grade of C or better in CHEM 102. Corequisites: MATH 285, and PHYS 101 or PHYS 102.

CHEM 310. Physical Chemistry II. 3 Credits.

The application of thermodynamics to the study of the states of matter, phase equilibria, chemical equilibria, thermal chemistry, and electrochemistry. Chemical kinetics, diffusion and the migration of ions. Elucidation of the molecular structure of matter by classical physical and quantum mechanical considerations. Prerequisites:A grade of C or better in CHEM 102. Co-requisite: MATH 285 and PHYS 101 or PHYS 102.

CHEM 311. Physical Chemistry Laboratory I. 2 Credits.

Laboratory studies of physical chemical measurements on gases, heats of chemical processes, equilibrium, emf and conductance. A four hour laboratory. Pre-requisite: A grade of C or better in CHEM 309. Corequisite: CHEM 310.

CHEM 319. Organic Chemistry I. 3 Credits.

The chemistry of carbon compounds. Emphasis on structure and mechanisms of organic reactions. Three lectures and one problem period. Prerequisite: A grade of C or better in CHEM 102.

CHEM 320. Organic Chemistry II. 3 Credits.

The chemistry of carbon compounds. Emphasis on structure and mechanisms of organic reactions. Three lectures and one problem period. Prerequisite: A grade of C or better in CHEM 319.

CHEM 323. Organic Chemistry Laboratory I. 2 Credits.

Synthesis, purification, analysis, mechanistic studies and spectral characterization of organic compounds. Four hours of laboratory. Pre-requisite: A grade of C or better in CHEM 319. Co-requisite: CHEM 319.

CHEM 324. Organic Chemistry Laboratory II. 2 Credits.

Synthesis, purification, analysis, mechanistic studies and spectral characterization of organic compounds. Four hours of laboratory. Prerequisite: CHEM 323. Co-requisite: A grade of C or better in CHEM 323.

CHEM 335. Inorganic Chemistry. 3 Credits.

The chemistry of the elements and their compounds. Industrial, biochemical, environmental, and geochemical applications of inorganic chemistry are emphasized. The periodic table, elementary bonding models and thermodynamic data are used to organize, understand, and predict chemical and physical properties of inorganic compounds. Three lectures. Prerequisite: A grade of C or better in CHEM 102.

CHEM 336. Inorganic Chemistry Laboratory. 2 Credits.

Study of the properties, synthesis and characterization of inorganic compounds. Experiments include preparations of metallic and non-metallic elements from compounds; simple salts by wet and dry methods; common gases; coordination compounds; air sensitive compounds; organometallic compounds; high temperature superconductors. A four hour laboratory. Prerequisite or Co-requisite: A grade of C or better in CHEM 335.

CHEM 375. Internship for Juniors. 3 Credits.

Students participate in an off-campus training experience closely related to one of the areas of chemistry or biochemistry. Frequent meetings with the advisor plus a paper are required. Prerequisites: Junior status, 3.0 GPA, and permission of the student's advisor or the Chair.

CHEM 410. Physical Chemistry Laboratory II. 2 Credits.

Laboratory studies of kinetics, spectroscopy, molecular structure and molecular modeling. A four hour laboratory. Prerequisite or Co-requisite: A grade of C or better in CHEM 311.

CHEM 415. Advanced Organic Chemistry. 3 Credits.

Structure, mechanism and synthesis in modern organic chemistry. An introduction to the chemistry of natural products and heterocyclic compounds will be included. Three lectures. Prerequisite: CHEM 320.

CHEM 421. Advanced Topics in Chemistry. 3 Credits.

Advanced topics in chemistry will be chosen from several areas of chemistry on a rotating basis. Current course offerings include transition metal catalysts in organic synthesis, polymer chemistry, environmental chemistry, industrial chemistry, physical organic chemistry, applications of organic chemistry (dyes and fragrance/flavor chemistry) and an advanced synthesis laboratory. Other topics of current interest can be added at the discretion of the department. A student may elect the course more than once if the topics are different each time. Three lecture hours or eight laboratory hours per week. Repeatable. Prerequisites: CHEM 310, CHEM 320.

CHEM 427. Advanced Physical Chemistry. 3 Credits.

Topics in theoretical physical chemistry with an introduction to the chemical aspects of quantum and statistical mechanics, and group theory. Three lectures. Prerequisite: CHEM 310.

CHEM 433. Biochemistry I. 3 Credits.

An introduction to the chemistry of biologically important amino acids, proteins, carbohydrates, lipids, vitamins and hormones. Enzyme kinetics and catalysis, protein structure and function, introduction to intermediary metabolism will be included. Three lectures. Prerequisite: A grade of C or better in CHEM 320.

CHEM 434. Biochemistry II. 3 Credits.

Chemistry and metabolism of proteins, carbohybrates, and lipids. Protein folding and posttranslational modification. Three lectures. Prerequisite: A grade of C or better in CHEM 433.

CHEM 435. Advanced Inorganic Chemistry. 3 Credits.

Molecular structure and bonding theory. Transition metal chemistry. An introduction to spectroscopy, catalysis, and organometallic chemistry. Three lectures. Prerequisites: CHEM 310 and CHEM 335.

CHEM 436. Biochemistry Laboratory. 2 Credits.

Four hour laboratory with emphasis on techniques used in protein and enzymology laboratories. Prerequisite or Co-requisite: A grade of C or better in CHEM 434.

CHEM 437. Computers, Structures and Bonding. 3 Credits.

An intermediate level presentation of the fundamental ideas of metallic, ionic and covalent bonding. The consequences of these bonding schemes are then related to the plenitude of three dimensional chemical, biochemical, and crystalline structure. The latest computer software of interest to chemists and biochemists is incorporated in a hands on approach in order to render chemical structures and deduce chemical properties based on the bonding pertinent to those structures using the computer for chemical literature searching and manuscript preparation. Three lectures. Prerequisites: A grade of C or better in CHEM 309, CHEM 320 and CHEM 335.

CHEM 452. Advanced Spectroscopy. 5 Credits.

Molecular UV/Vis absorption and luminescence spectroscopy; atomic absorption and emission spectroscopy; nuclear magnetic resonance spectrometry; infrared and Raman spectroscopy; mass spectroscopy. Three lectures and a four hour laboratory. Prerequisites: A grade of C or better in CHEM 302, CHEM 310, CHEM 320, CHEM 324 and CHEM 410.

CHEM 457. Biochemistry III. 3 Credits.

Biochemistry of the nucleic acids, DNA and RNA. Three lectures. Fall. Prerequisite: A grade of C or better in CHEM 434.

CHEM 459. Biochemistry III Laboratory. 2 Credits.

Four hours of laboratory with emphasis on techniques used in nucleic acid laboratories. Spring. Prerequisite: A grade of C or better in CHEM 457.

CHEM 460. Chemical Research. 1 Credit.

An investigation of an original nature carried out by the student under the guidance of a faculty member; a brief written report is submitted to and approved by the faculty of the department.

CHEM 461. Chemical Research. 2 Credits.

An investigation of an original nature carried out by the student under the guidance of a faculty member; a brief written report is submitted to and approved by the faculty of the department.

CHEM 475. Internship for Seniors. 3 Credits.

Students participate in an off-campus training experience closely related to their area of chemistry or biochemistry. Frequent meetings with the advisor plus a paper are required. Prerequisites: Senior status, 3.0 GPA, and permission of the student's advisor or the Chair.

CHEM 571. Physical Biochemistry. 3 Credits.

Quantitative characterization and analysis of macromolecules with applications of biochemistry and molecular biology. Emphasis on the principles and application of laboratory techniques including chromatography, electrophoresis, hydrodynamic methods and spectroscopy. Three lectures. Prerequisite: CHEM 434.

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